Active compounds from combinatorial syntheses should be re-synthesised and retested to verify biological activity. RSC Medicinal Chemistry is part of the collection RSC Gold, Online only 2021: ISSN 2632-8682, £1,646 / $2,439,
We're sorry, your email could not be sent. Portoghese had served as editor-in-chief from 1972-2011. You can find details about how to access information remotely in this step-by-step guide. It will help readers to decide whether your article is of interest to them. Additional guidance on the layout and formatting of the article and supplementary information can be found on our Prepare your article page. Doses and concentrations should be expressed as molar quantities (for example, mol kg-1, µmol kg-1, M, µM). For new derivatives comprising modified monomers, the usual organic chemistry analytical requirements for the novel monomer must be provided. To better understand these biological processes, investigation of the in vivo kinetics of AGEs, i.e., analysis of trafficking and clearance properties, was carried out by molecular imaging. Details of the types of computational studies that are suitable for publication in RSC Medicinal Chemistry are given in the “Scope” section above. A platinum complex/peptide chimera shows specific DNA binding and covalent platination with potential as a novel chemotherapeutic. Think about what would grab the attention of a reader as they scan though article listings, include only one or two key elements (these graphics are small). Opinions are typically three to four pages in length and are normally published by invitation of the RSC Medicinal Chemistry Editorial Board or Editorial Office. Reviews should focus on the key developments that have shaped the topic, rather than comprehensive reviews of the literature. Computational methods should be described in sufficient detail such that a scientist skilled in the art would be able to reproduce the results presented. More information on the Royal Society of Chemistry journals’ ethical policies can be found in our Author responsibilities page. Where HPLC is used conditions employed should be supplied including column type, flow rate, solvent system and detection method. It should emphasise (but not overstate) the significance and potential impact of the research in your article. Chem. When a study involves the use of live animals or human subjects, authors must include in the 'methods/experimental' section of the manuscript a statement that all experiments were performed in compliance with the relevant laws and institutional guidelines, and must state the institutional committee(s) that has approved the experiments. To be considered for RSC Medicinal Chemistry such studies should demonstrate significant potential to advance the field of medicinal chemistry. Authors should use a number of significant figures that is relevant to the accuracy of the data. Reviewers may be asked to comment specifically on any cases in which concerns arise. The Journal of Medicinal Chemistry is a peer-reviewed medical journal covering research in medicinal chemistry. For all tested compounds purity should be at least 95%, confirmed by either, For key compounds (those which are subject to further study beyond initial screening), additional data should include, For chiral compounds, when used as a non-racemate, specific rotation and evidence of enantiomeric purity via chiral HPLC or derivatisation to diastereoisomeric compounds/use of chiral shift reagents should be given. The length can vary from 40 to 150 words, but it should always be concise and easy to read, with recognisable words and phrases. Further details, including advice on disabling cookies, are available in our. Authors are encouraged to summarise important findings instead of re-iterating details already available in the primary work and should provide summary figures instead of multiple figures from original manuscripts, where appropriate. Novel macromolecular structures and newly reported nucleic acid or protein sequences and microarray data must be deposited with the appropriate database. Design, synthesis and biological evaluation of novel chemical or biochemical entities. For those compounds found to be inactive, the highest concentration (in vitro) or dose level (in vivo) tested should be indicated. Vast numbers of prevalent aminoglycoside-modifying enzymes undermine the clinical use of aminoglycoside antibiotics. Where computational studies are accompanied by experimental results (for example to validate a prediction) those experimental procedures and data should also be described in detail (see guidelines for experimental procedures above). ISSN: 0022-2623. Use keywords and familiar, searchable terms – these can increase the chances of your article appearing in search results. In vivo imaging and fluorescence microscopy analysis revealed that non-enzymatic AGEs were smoothly captured by scavenger cells in the liver, i.e., Kupffer and other sinusoidal cells, but were unable to be properly cleared from the body. Analogue synthesis of an initial hit compound led to the discovery of a potentially new class of small molecule adjuvants containing an indole core. 2019 Impact Factor. The Comment and Reply will be published together. Chemical structures should not be blanked out. This significance statement should focus specifically on the importance of the piece of research being submitted, rather than the importance of the field. Quantitative biological data are required for all test compounds. For in vivo studies vehicle information should be supplied. We present the design and synthesis of a potent broad-spectrum bactericidal aminoglycoside based on available X-ray co-crystal structures within the ribosomal binding-site. Forms of administration as well as physical states and formulations should be noted. While our publishing services are running as usual, we also know that this is a very challenging time for everyone, for many different reasons. They succeeded Philip S. Portoghese (University of Minnesota) in 2012. We also welcome shorter, mini-review style articles under this article type. Research articles have no page limits, although most articles fall between 4 and 10 journal pages (approximately 10–25 pages of double-spaced text).Research Articles encompass both full paper and communication styles. The resulting antibiotic displays broad protection of its functional groups from inactivation by clinically relevant resistance enzymes. All new research in RSC Medicinal Chemistry is published in the Research article format. Self-nominations are accepted but must be accompanied by a letter of support from the Head of Department or similar person at the institute. The table of contents graphic should give the reader a clear indication of the topic of the study, for example by showing key compounds. 2010, 53, 2719-2740. RSC Medicinal Chemistry is the new name for MedChemComm. Studies which report novel computational methodology must demonstrate its use in medicinal chemistry through comparison with experimental data. It is published by the American Chemical Society. Where a communication style article is submitted the work should be of enough importance to merit urgent publication before the full study is complete. It’s much better to have a small amount of information that stands out rather than a lot of information that is too small to read, be large enough to read and in Arial, Times or Helvetica font, focus only on the key findings and their importance, not the processes used. EndNote Styles - Journal of Medicinal Chemistry. The synthesis of all new compounds must be described in detail. Modifications of known chemical or biochemical entities that result in a significantly greater understanding of their structure-activity relationships, an improvement of their properties or which provide other information of significant value, for example, the identification of a new target for a known agent. Researchers in academia and industry studying medicinal chemistry, pharmacology, and topics in the wider chemical, biological and materials sciences with application to biological problems. Authors are particularly encouraged to prepare a title and abstract which concisely summarise the key findings of their research and their importance, avoiding the use of non-standard abbreviations, acronyms and symbols, as this will enable potential readers to quickly understand the significance of the research. Standard studies must be accompanied by new experimental data which tests their predictive power.
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