2020 295: 15183. doi:10.1074/jbc.RA120.014466, Exosite binding drives substrate affinity for the activation of coagulation factor X by the intrinsic Xase complex, Manjunath Goolyam Basavaraj and Sriram Krishnaswamy, J. Biol. The RS was < 11 in 55 patients, 11–25 in 241, and > 25 in 43. medication to treat this devastating disease. Here we review the pathogenesis of NAFLD and the impact of AMPK activity state on hepatic steatosis, inflammation, liver Totally, 233 patients (68.7%) had T1 tumors while 105 (31.0%) had T2 tumors. Breast cancer (version 3.2020). Clin Cancer Res 2014;20:5272–5280. JBC’s at the top of the list of the most frequently chosen journals for publishing NIH-funded research. A total of 302 patients received conventional fractionated RT (50–50.4 Gy in 25–28 fractions) and 37 received hypofractionated RT (39–43.2 Gy in 13–16 fractions). On the basis of these findings, the National Comprehensive Cancer Network guidelines recommend that regional RT should be considered even for node-negative patients with central/medial tumors or for patients with tumors > 2 cm with risk factors such as young age or extensive lymphovascular invasion [3]. publishing charge: US$2,000 for ASBMB members and US$2,500 for nonmembers.These papers will be published under a CC-BY license. Mamounas EP, Liu Q, Paik S, Baehner FL, Tang G, Jeong JH, et al. In the current study, the surgical resection margin was involved in 18 patients (15 with invasive carcinoma and 3 with intraductal carcinoma), but all of them were free of LRR. Journal Rank (SCImago): Value of Chem. A. R. S. is a founder of Elgia Therapeutics. About JBC. Effect of radiotherapy in earl-stage, low-recurrence risk, hormone-sensitive breast cancer. Chem. Adapted from the recommendation of the International Committee of Medical Journal Editors (ICMJE) Bioxbio.com includes the journal factors, ISSN, number of articles and other detailed information of over 11000 journals in different fields. N Engl J Med 2015;373:317–327. Shining light on rhodopsin selectivity: How do proteins decide whether to transport H+ or Cl–? J. Biol. Ann Surg Oncol 2015;22:1088–1094. Jayasekera J, Schechter CB, Sparano JA, Jagsi R, White J, Chapman JW, et al. the scientists involved. A single‐cell RNA‐seq resource identifies expression of coronavirus entry‐linked host cofactors. ctSCAN-SMS identifies regulatory elements of Oct4, Ataxin-2 mediates cytoplasmic polyadenylation, A physical basis for quantitative ChIP-Seq. 5-Year Impact Factor. Paik S, Shak S, Tang G, Kim C, Baker J, Cronin M, et al. The RS was < 11 in 55 patients (16.2%), 11–25 in 241 patients (71.1%), and >25 in 43 patients (12.7%). Liangjun Zhao, Gary P. Newnam, Kavita R. Matange, Hem R. Thapa, Brett Barlow, Rebecca K. Donegan, Nguyet A. Nguyen, Emily transplant and liver-associated death. The regional recurrence sites were the axillary LNs in 2 patients and the supraclavicular LN in 1 patient, none of whom had received regional RT initially. The Journal of Biological Chemistry welcomes high-quality science that seeks to elucidate the molecular and cellular basis of biological processes. One patient had multicentric tumors. Editors’ Picks, formerly called Papers of the Week, represent the top-rated papers published in JBC across the field of biological chemistry, as determined by our Associate Editors, Editorial Board Members and other referees. Impact of the boost dose of 10 Gy versus 26 Gy in patients with early stage breast cancer after a microscopically incomplete lumpectomy: 10-year results of the randomised EORTC boost trial. 2020 295: 15174. doi:10.1074/jbc.RA120.015249, HIV-cell membrane fusion intermediates are restricted by Serincs as revealed by cryo-electron and TIRF microscopy, Amanda E. Ward, Volker Kiessling, Owen Pornillos, Judith M. White, Barbie K. Ganser-Pornillos, and Lukas K. Tamm, J. Biol. While the RS was initially known to be associated with distant metastasis [7], subsequent studies showed that it also predicts locoregional recurrence (LRR) [8, 9, 10]. A total of 265 patients received tamoxifen, 62 received an aromatase inhibitor, and 8 received tamoxifen initially and switched to an aromatase inhibitor. Architecture of the centriole cartwheel-containing region revealed by cryo-electron tomography, Microbiology, Virology & Host Pathogen Interaction, Post-translational Modifications & Proteolysis, Olesia Ignatenko, Joni Nikkanen, Alexander Kononov, Nicola Zamboni, Gulayse Ince-Dunn, Anu Suomalainen. 31 July 2020 Mitochondrial spongiotic brain disease: astrocytic stress and harmful rapamycin and ketosis effect Astrocyte-specific mtDNA depletion causes spongiotic encephalopathy, aggravated by ketogenic diet or rapamycin. 21-Gene recurrence score and locoregional recurrence in lymph node-negative, estrogen receptor-positive breast cancer. Totally, 339 patients from 4 institutions were enrolled and analyzed retrospectively. Kinetic analyses of ERAD E3 (Hrd1, Doa10) and E2 (Ubc6, Ubc7) enzymes reveal the rate‐limiting nature of the ubiquitin chain priming step, and the molecular basis for respective E2 preferences of these E3s during priming. PID‐2 and its newly‐identified interactors PID‐4 and PID‐5 modulate size and appearance of Z granules to establish and maintain stable heritable silencing (RNAe) by maternal piRNAs. First Published on July 10, 2020 doi: 10.1074/jbc.REV120.011356 August 21, 2020 The Journal of Biological Chemistry 295, 12279-12289. Chem. Although risk factor analysis could not be performed owing to the small number of events, all the 4 cases of LRR were observed in patients with a high RS, consistent with the observations in previous studies. the authors and does not necessarily represent the official views of the National Institutes of Health. ClinicalTrials.gov. Article Influence: A measure of a journal's prestige based on per article citations and comparable to Impact Factor. All LRRs were observed among patients with a RS > 25, resulting in a 5-year LRR rate of 7.3% in this subgroup. Woodward WA, Barlow WE, Jagsi R, Buchholz TA, Shak S, Baehner F, et al. Although these studies suggest that the LRR rate was significantly separated by using the RS, the differences in the local and systemic treatments as well as the follow-up duration should be considered in the interpretation. In addition, as LRR was observed in only 4 patients, risk factors such as surgical resection margin could not be analyzed further. The Walter and Eliza Hall Institute of Medical Research (WEHI), Max Delbrück Center for Molecular Medicine. Considering the correlation between the RS and LRR, many studies are underway to guide the optimal indications of RT. [16] analyzed the correlation between the RS and LRR in a subgroup of the NSABP B-28 trial, in which all patients were treated with chemotherapy and hormonal therapy. Small GTPase Rabl2 regulates ciliary signaling, but not ciliogenesis, by gating the exit of membrane receptors through the ciliary transition zone. Regarding the tumor location, 119 patients had inner tumors, 170 had outer tumors, and 49 had central tumors. As regional recurrence was observed only in patients with a RS > 25 who were treated with only breast RT, regional RT might be considered for those patients with a high RS. Mamounas EP, Tang G, Fisher B, Paik S, Shak S, Costantino JP, et al. Sjöström M, Chang SL, Fishbane N, Davicioni E, Zhao SG, Hartman L, et al. Insights into the architecture of uromodulin filaments involved in the capture of uropathogenic bacteria, and structurally‐related vertebrate egg coat material, suggest how a widespread extracellular polymerization module can support multiple functions. Among the various genomic biomarkers, the Oncotype DX recurrence score (RS) is the most popular biomarker for patients with node-negative, hormone receptor-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer. Reconstitution of maximal mitochondrial respiration circumvents the limitations associated with current methods for assessing mitochondrial bioenergetics in frozen clinical samples. All the patients underwent BCS and sentinel lymph node (LN) biopsy, or BCS and axillary LN dissection. A multipronged approach allowed engineering of an optimized A > I RNA base editor facilitating specific and efficient base editing. Breast Cancer Res Treat 2017;166:69–76. Lancet 2011;378:1707–1716. ISSN: 0021-9525. A total of 164 patients had right breast cancer and 175 had left breast cancer. All the patients underwent BCS and RT, and 88% of patients with a RS > 25 received chemotherapy. JAMA Oncol 2020;6:505–511. (Scientific image by Gabriel Aeschlimann, Ribosome Studio), By Nikolai Klena, Maeva Le Guennec, Benjamin D Engel, Virginie Hamel, Paul Guichard and colleagues. Radiother Oncol 2009;90:80–85. The IDEA study (individualized decisions for endocrine therapy alone). In conclusion, excellent locoregional control was achieved in patients with node-negative, hormone receptor-positive/HER2-negative breast cancer who underwent BCS plus RT—including risk-adapted systemic therapy—according to the Oncotype DX RS. The detailed summary of recurrences is shown in Table 2. J Breast Cancer. Journal Citation Reports (Clarivate Analytics, 2020) 5-Year Impact Factor: 7.105 ℹ Five-Year Impact Factor: 2019: 7.105

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