SELF may earn a portion of sales from products that are purchased through our site as part of our Affiliate Partnerships with retailers. These processed chemical sweeteners are not safe alternatives to sugar. As we explored in detail in an earlier article, aspartame is anything but safe, and is actually the most dangerous artificial sweetener on the market. Advantame -- which does not yet having a catchy marketing name -- is the sixth artificial sweetener on the U.S. market to receive the FDA’s blessing as a safe food additive. (7)   Some of the reported side effects include headaches, nausea, dizziness, weakness, and change in heart rate, seizures, difficulty breathing, sleep problems and neurological reactions. However, according to the FDA, since advantame is many times sweeter than aspartame, a much smaller amount has to be used in order to achieve the same level of sweetness, so products containing advantame won’t be required to carry the same info statement alerting people with PKU about the presence of phenylalanine. Splenda and Stevia step aside, there's a new sweetener in town. For individuals with phenylketonuria (PKU), a genetic disorder, phenylalanine is especially dangerous, and can lead to seizures, brain damage and even death. It degrades faster at higher temperatures and humidity, but is generally more stable than aspartame. [1], The Center for Science in the Public Interest ranks advantame as safe[7] and Flavor and Extract Manufacturers Association as generally recognized as safe. In addition to as-yet limited studies, research continues to link artificial sweeteners with weight gain. )É©L^6 ‹gş,qmé¢"[šZ[Zš™~Q¨ÿºø7%îí"½ First of all, this is not really that many studies when it comes to a processed substance that people will be consuming in a variety of foods. According to Science Direct, advantame is an N-substituted (aspartic acid portion) derivative of aspartame that is similar in structure to Neotame, another N-substituted aspartame. The concern, of course, with these sweeteners is their safety. Advantame, which does not yet have a brand name, is described as a “high intensity sweetener” 20,000 times sweeter than sugar. (3) Advantame is 20,000 times sweeter, gram per gram, than table sugar, making it the sweetest, by far, of the artificial sweeteners currently on the market. At first advantame was identified by the laboratory code ANS9801. If you believe that you are having an adverse reaction caused by consuming a high-intensity sweetener, stop consuming it immediately and discuss your concerns with your health care provider. Advantame is a chemical derivative of the artificial sweetener, aspartame, which certain individuals should avoid or limit. SELF does not provide medical advice, diagnosis, or treatment. $E}k¿ñÅyhây‰RmŒ�333�¸–‘¸ ¿ë:ü }ñ=#ñv¿—‡îʉe How sweet is Advantame? QfÊ ÃMlˆ¨@DE� €£¡H¬ˆb!(¨`HPb0Š¨¨dFÖJ|yyïåå÷ǽßÚgïs÷Ù{Ÿµ. endstream endobj 34 0 obj <> endobj 35 0 obj <>stream It has been approved for use in baked goods, frozen desserts, soda and other processed foods. The advantage of using advantame, like other sweeteners, is that it contributes very few if any calories to foods and does not affect blood sugar levels in the same way that traditional sugar does. To approve advantame's safety, the FDA reviewed 37 scientific animal and human studies looking at possible toxic effects and deemed the product safe for the public. [2] Vanillin is transformed to HMPA in 4 steps. Advantame has 2 stereocenters and 4 stereoisomers. Advantame is poorly absorbed, rapidly metabolized and only small amounts of it and its metabolites can be detected in blood shortly after ingestion. 1% of the ingested dose is excreted in urine as the aforementioned aspartic acid analog, 1.9% as 5-(3-aminopropyl)-2-methoxyphenyl and 2.3% as de-esterified advantame. High levels of phenylalanine have been associated with behavior changes such as ADD, as well as to worsening diabetes symptoms. 1. http://www.janethull.com/healthynews/blog/2014/05/advantame-the-newest-version-of-aspartame-same-song-just-another-verse/, 2. http://www.aji-aspartame.com/index.asp, 3. https://www.federalregister.gov/articles/2014/05/21/2014-11584/food-additives-permitted-for-direct-addition-to-food-for-human-consumption-advantame, 4. http://www.aji-aspartame.com/products/advantame.asp, 6. http://www.sciencedirect.com/science/article/pii/S0278691511002900, 7. http://articles.mercola.com/sites/articles/archive/2011/11/06/aspartame-most-dangerous-substance-added-to-food.aspx, 8. http://www.fda.gov/ohrms/dockets/dailys/03/Jan03/012203/02P-0317_emc-000199.txt, 9. http://www.cbsnews.com/news/fda-approves-new-artificial-sweetener/, 10.http://www.fda.gov/Food/IngredientsPackagingLabeling/FoodAdditivesIngredients/ucm397716.htm, 11. http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm397711.htm, 12. http://www.marketwatch.com/story/were-eating-more-sugar-less-splenda-2013-05-13.

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